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Quiz

Pharmacognosy - 5.17 Enzymes

Enzymes in Pharmacognosy

Enzymes

By Mr. Bhosale, SKCP, Kasbe Digraj

How to Access the Quiz for This Chapter

Click on Quiz on the right → enter your Details → select D. Pharmacy → choose Pharmacognosy → then select 5.17 Enzymes.

Enzymes are biological molecules that act as catalysts in various biochemical reactions within living organisms. They are considered as crude drugs in the field of pharmacognosy due to their therapeutic properties and natural origin. Enzymes play a crucial role in the metabolism of drugs and other substances in the body.

Examples of Enzymes and Their Sources

Papaya (Source of Papain)

Synonyms

Papaya, Pawpaw

Regional Names

Hindi: पपीता (Papita)
Marathi: पपई (Papai)

Biological Source

Fruit, Latex, Leaves, Seeds of Carica papaya (कारिका पपया). Native to India.

Family

Caricaceae (कैरिकेसी)

Major Chemical Constituents

  • Enzymes: Papain, Chymopapain
  • Carotenoids: Beta-carotene, Lycopene
  • Vitamins: Vitamin C, Vitamin A, Vitamin E
  • Flavonoids: Quercetin, Kaempferol

Minor Chemical Constituents

Fiber, Minerals (Potassium, Magnesium, Calcium), Phenolic compounds, Essential oils

Uses

  • Primary Use: Digestive Aid (Papain)
  • Additional Uses: Wound Healing, Anti-Inflammatory, Antioxidant Effects, Antimicrobial Activity, Skin Care.

Diastase (from Barley)

Synonyms

Diastase (डायस्टेज)

Biological Source

Germinating barley seeds, particularly from malted barley (Hordeum vulgare - हॉर्डियम वल्गारे).

Family

Poaceae (पोएसी)

Major Chemical Constituents

  • Enzymes: Amylase (Alpha-amylase, Beta-amylase)
  • Proteins, Carbohydrates

Minor Chemical Constituents

Lipids, Minerals, Vitamins

Uses

  • Primary Use: Digestive Aid (Starch digestion)
  • Additional Uses: Pharmaceutical Excipient, Food Industry (Brewing, baking)

Pancreatin

Synonyms

Pancreatin (पैंक्रिएटिन)

Biological Source

Pancreatin is derived from the pancreas of animals, typically from pigs (Sus scrofa) or cattle (Bos taurus).

Family

Suidae (for pigs) – सुइडी
Bovidae (for cattle) – बोविडी

Major Chemical Constituents

  • Amylase
  • Lipase
  • Protease (including Trypsin and Chymotrypsin)

Minor Chemical Constituents

Elastase, Carboxypeptidase, Minerals and Vitamins.

Uses

  • Primary Use: digestive enzyme supplement in individuals with pancreatic insufficiency, where the pancreas does not produce adequate enzymes for digestion.
  • Additional Uses:
    • Enzyme replacement therapy for conditions such as cystic fibrosis, chronic pancreatitis, and pancreatectomy.
    • Helps in the digestion and absorption of nutrients, reducing bloating and malabsorption-related symptoms.

Yeast

Synonyms

Yeast

Biological Source

Derived from various species of fungi, primarily Saccharomyces cerevisiae (सॅक्रोमायसीस सेरेविसी).

Family

Saccharomycetaceae (सॅक्रोमायसेटेसी)

Major Chemical Constituents

  • Proteins
  • Carbohydrates: Glucose, Fructose (Also complex carbohydrates like glucans, mannans)
  • Nucleic acids: DNA, RNA
  • B Vitamins: Thiamine, Riboflavin, Niacin, Folic Acid (Also B6, Biotin, Pantothenic acid)

Minor Chemical Constituents

  • Lipids
  • Minerals: Potassium, Magnesium, Calcium (Also Phosphorus, Zinc, etc.)
  • Enzymes: Amylase, Protease (Also Invertase, Zymase complex, etc.)

Uses

  • Primary Use: Probiotic Function: promote gut health and prevent antibiotic-associated or infectious diarrhea (specific strains like *S. boulardii*).
  • Additional Uses: Vitamin Supplementation (Nutritional Yeast), Vaccine Production (e.g., Hepatitis B vaccine components), Fermentation Agent (Baking, Brewing).
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