Pharmacognosy - 5.17 Enzymes
Enzymes
By Mr. Bhosale, SKCP, Kasbe Digraj
How to Access the Quiz for This Chapter
Click on Quiz on the right → enter your Details → select D. Pharmacy → choose Pharmacognosy → then select 5.17 Enzymes.
Enzymes are biological molecules that act as catalysts in various biochemical reactions within living organisms. They are considered as crude drugs in the field of pharmacognosy due to their therapeutic properties and natural origin. Enzymes play a crucial role in the metabolism of drugs and other substances in the body.
Examples of Enzymes and Their Sources
Papaya (Source of Papain)
Synonyms
Papaya, Pawpaw
Regional Names
Hindi: पपीता (Papita)
Marathi: पपई (Papai)
Biological Source
Fruit, Latex, Leaves, Seeds of Carica papaya (कारिका पपया). Native to India.
Family
Caricaceae (कैरिकेसी)
Major Chemical Constituents
- Enzymes: Papain, Chymopapain
- Carotenoids: Beta-carotene, Lycopene
- Vitamins: Vitamin C, Vitamin A, Vitamin E
- Flavonoids: Quercetin, Kaempferol
Minor Chemical Constituents
Fiber, Minerals (Potassium, Magnesium, Calcium), Phenolic compounds, Essential oils
Uses
- Primary Use: Digestive Aid (Papain)
- Additional Uses: Wound Healing, Anti-Inflammatory, Antioxidant Effects, Antimicrobial Activity, Skin Care.
Diastase (from Barley)
Synonyms
Diastase (डायस्टेज)
Biological Source
Germinating barley seeds, particularly from malted barley (Hordeum vulgare - हॉर्डियम वल्गारे).
Family
Poaceae (पोएसी)
Major Chemical Constituents
- Enzymes: Amylase (Alpha-amylase, Beta-amylase)
- Proteins, Carbohydrates
Minor Chemical Constituents
Lipids, Minerals, Vitamins
Uses
- Primary Use: Digestive Aid (Starch digestion)
- Additional Uses: Pharmaceutical Excipient, Food Industry (Brewing, baking)
Pancreatin
Synonyms
Pancreatin (पैंक्रिएटिन)
Biological Source
Pancreatin is derived from the pancreas of animals, typically from pigs (Sus scrofa) or cattle (Bos taurus).
Family
Suidae (for pigs) – सुइडी
Bovidae (for cattle) – बोविडी
Major Chemical Constituents
- Amylase
- Lipase
- Protease (including Trypsin and Chymotrypsin)
Minor Chemical Constituents
Elastase, Carboxypeptidase, Minerals and Vitamins.
Uses
- Primary Use: digestive enzyme supplement in individuals with pancreatic insufficiency, where the pancreas does not produce adequate enzymes for digestion.
- Additional Uses:
- Enzyme replacement therapy for conditions such as cystic fibrosis, chronic pancreatitis, and pancreatectomy.
- Helps in the digestion and absorption of nutrients, reducing bloating and malabsorption-related symptoms.
Yeast
Synonyms
Yeast
Biological Source
Derived from various species of fungi, primarily Saccharomyces cerevisiae (सॅक्रोमायसीस सेरेविसी).
Family
Saccharomycetaceae (सॅक्रोमायसेटेसी)
Major Chemical Constituents
- Proteins
- Carbohydrates: Glucose, Fructose (Also complex carbohydrates like glucans, mannans)
- Nucleic acids: DNA, RNA
- B Vitamins: Thiamine, Riboflavin, Niacin, Folic Acid (Also B6, Biotin, Pantothenic acid)
Minor Chemical Constituents
- Lipids
- Minerals: Potassium, Magnesium, Calcium (Also Phosphorus, Zinc, etc.)
- Enzymes: Amylase, Protease (Also Invertase, Zymase complex, etc.)
Uses
- Primary Use: Probiotic Function: promote gut health and prevent antibiotic-associated or infectious diarrhea (specific strains like *S. boulardii*).
- Additional Uses: Vitamin Supplementation (Nutritional Yeast), Vaccine Production (e.g., Hepatitis B vaccine components), Fermentation Agent (Baking, Brewing).