Pharmacognosy - 5.19 Miscellaneous
Miscellaneous
By Mr. Bhosale, SKCP, Kasbe Digraj
How to Access the Quiz for This Chapter
Click on Quiz on the right → enter your Details → select D. Pharmacy → choose Pharmacognosy → then select 5.19 Miscellaneous.
This category includes drugs that:
- They don\'t belong exclusively to a single chemical or pharmacological category.
- They have multiple uses or constituents with diverse actions.
- It helps students study such important, widely used herbs without forcing them into ill-fitting categories.
Squill
Synonym:
English: Sea onion, Sea squill, Scilla, Urginea, Jangli Pyaj.
Biological Source:
Squill is derived from the dried slices of the bulb of Urginea indica.
Family:
Liliaceae
Chemical Constituents:
- Major Chemical Constituents:
- Cardiac glycosides: scillaren A (a pure crystalline substance), scillaren B (an amorphous mixture of glycosides)
- Minor Chemical Constituents: flavonoids, sinistrin, mucilage (4 to 11 percent) and calcium oxalate
Uses:
- Squill is a cardiotonic similar to digitalis, but it is generally not used medicinally due to toxicity concerns. It can cause stomach irritation, loss of appetite, diarrhea, vomiting, headache, vision changes, depression.
- Squill is sometimes used as an expectorant, a diuretic, an emetic, and a stimulant (often in traditional or historical contexts, not standard modern practice due to toxicity).
- Used as a rodenticide (Red Squill variety).
Galls (Oak Galls)
Synonym:
English: oak galls, nutgalls, gall nuts, or oak apples.
Hindi: Majuphal (मंजूफल)
Biological Source:
One of the most common sources of galls is the Aleppo oak, Quercus infectoria. (Excrescences formed by insect larvae, typically Cynips species, on the twigs).
Family:
Fagaceae
Chemical Constituents:
- Major Chemical Constituents: Galls contain the highest naturally occurring level of tannin (hydrolyzable tannins), approximately 50–70%, including gallic and ellagic acids.
- Minor Chemical Constituents: flavonoids, phenolic compounds, syringic acid, β-sitosterol
Uses:
- Galls have also been used traditionally for fever, intestinal ailments (astringent/anti-diarrheal), asthma, alopecia, edema, heart disease.
- Galls have antiseptic, antibacterial, antifungal, anti-inflammatory, antioxidant, antidiabetic, anticancer, and immunomodulatory properties (mostly demonstrated in vitro or traditionally claimed).
- Primary use as a source of tannins for dyeing and ink production (historically).
- Astringent in topical preparations or gargles.
Ashwagandha
Synonym:
English: Indian ginseng, Winter cherry, Poison gooseberry.
Biological Source:
Derived from the dried roots and stem bases of Withania somnifera. Ashwagandha is native to India.
Family:
Solanaceae
Chemical Constituents:
- Major Chemical Constituents:
- Withanolides: withaferin A, withanolide D, and withanone.
- Alkaloids: somniferine, isopelletierine, and anahygrine.
- Saponins: sitoindoside VII, sitoindoside VIII, and withanoside IV.
- Minor Chemical Constituents: Flavonoids, Amino acids, Volatile oils
Uses:
- Ashwagandha is used as an adaptogen, which means it helps the body cope with stress and anxiety.
- Enhancing the brain function and memory.
- Ashwagandha is used for improving the sexual health and fertility of both men and women.
- Ashwagandha is used for strengthening the immune system and reducing inflammation.
Tulsi
Synonym:
English: holy basil, sacred basil, Indian basil
Hindi & Marathi: Tulsi or Tulasi.
Biological Source:
Derived from the fresh or dried leaves and flowering tops of Ocimum sanctum (syn. *Ocimum tenuiflorum*).
Tulsi native to India.
Family:
Lamiaceae (Labiatae)
Chemical Constituents:
- Major Chemical Constituents: Include essential oil, tannins, flavonoids, phenolic acids, and triterpenoids.
- The essential oil consists mostly of eugenol (~70%), β-elemene (~11%), β-caryophyllene (~8%), and germacrene.
- Minor Chemical Constituents: The major flavonoids are orientin and vicenin, which have immunomodulatory and neuroprotective effects
Uses:
Tulsi has been shown to have adaptogenic, antimicrobial, anti-inflammatory, cardioprotective, antidiabetic, hepatoprotective, anticancer, and antistress effects
Guggul
Synonym:
English: gum guggul, guggula, gugul, Indian bdellium
Marathi: guggala
Biological Source:
Oleo-gum resin obtained by incision of the bark of Commiphora wightii (syn. *Commiphora mukul*).
Family:
Burseraceae
Chemical Constituents:
- Major Chemical Constituents: Contains gum (32%), essential oil (1.45%), sterols (guggulsterones I to VI, β-sitosterol, cholesterol, Z- and E-guggulsterone).
- The major constituents responsible for activity are guggulsterone E and Z, which are noted for lipid-lowering and potential weight reduction property.
- Minor Chemical Constituents: sugars (sucrose, fructose), amino acids
Uses:
- Guggul is praised for its anti-inflammatory properties, treat certain anti-inflammatory conditions, such as acne, eczema, psoriasis, and arthritis.
- It has also been used to promote weight loss, treat hypothyroidism
- Lipid-lowering (cholesterol and triglycerides) is a primary investigated use.