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Quiz

Pharmacognosy - 5.19 Miscellaneous

Miscellaneous Drugs in Pharmacognosy

Miscellaneous

By Mr. Bhosale, SKCP, Kasbe Digraj

How to Access the Quiz for This Chapter

Click on Quiz on the right → enter your Details → select D. Pharmacy → choose Pharmacognosy → then select 5.19 Miscellaneous.

This category includes drugs that:

  • They don\'t belong exclusively to a single chemical or pharmacological category.
  • They have multiple uses or constituents with diverse actions.
  • It helps students study such important, widely used herbs without forcing them into ill-fitting categories.

Squill

Synonym:

English: Sea onion, Sea squill, Scilla, Urginea, Jangli Pyaj.

Biological Source:

Squill is derived from the dried slices of the bulb of Urginea indica.

Family:

Liliaceae

Chemical Constituents:

  • Major Chemical Constituents:
    • Cardiac glycosides: scillaren A (a pure crystalline substance), scillaren B (an amorphous mixture of glycosides)
  • Minor Chemical Constituents: flavonoids, sinistrin, mucilage (4 to 11 percent) and calcium oxalate

Uses:

  • Squill is a cardiotonic similar to digitalis, but it is generally not used medicinally due to toxicity concerns. It can cause stomach irritation, loss of appetite, diarrhea, vomiting, headache, vision changes, depression.
  • Squill is sometimes used as an expectorant, a diuretic, an emetic, and a stimulant (often in traditional or historical contexts, not standard modern practice due to toxicity).
  • Used as a rodenticide (Red Squill variety).
Important Safety Note: Squill contains potent cardiac glycosides similar to Digitalis and is toxic. Its medicinal use is very limited and requires extreme caution due to the narrow therapeutic window and potential for severe side effects, including cardiac toxicity. It is not a standard treatment in modern medicine for cardiac conditions, and its use as an expectorant/emetic/diuretic is largely historical or traditional.

Galls (Oak Galls)

Synonym:

English: oak galls, nutgalls, gall nuts, or oak apples.
Hindi: Majuphal (मंजूफल)

Biological Source:

One of the most common sources of galls is the Aleppo oak, Quercus infectoria. (Excrescences formed by insect larvae, typically Cynips species, on the twigs).

Family:

Fagaceae

Chemical Constituents:

  • Major Chemical Constituents: Galls contain the highest naturally occurring level of tannin (hydrolyzable tannins), approximately 50–70%, including gallic and ellagic acids.
  • Minor Chemical Constituents: flavonoids, phenolic compounds, syringic acid, β-sitosterol

Uses:

  • Galls have also been used traditionally for fever, intestinal ailments (astringent/anti-diarrheal), asthma, alopecia, edema, heart disease.
  • Galls have antiseptic, antibacterial, antifungal, anti-inflammatory, antioxidant, antidiabetic, anticancer, and immunomodulatory properties (mostly demonstrated in vitro or traditionally claimed).
  • Primary use as a source of tannins for dyeing and ink production (historically).
  • Astringent in topical preparations or gargles.

Ashwagandha

Synonym:

English: Indian ginseng, Winter cherry, Poison gooseberry.

Biological Source:

Derived from the dried roots and stem bases of Withania somnifera. Ashwagandha is native to India.

Family:

Solanaceae

Chemical Constituents:

  • Major Chemical Constituents:
    • Withanolides: withaferin A, withanolide D, and withanone.
    • Alkaloids: somniferine, isopelletierine, and anahygrine.
    • Saponins: sitoindoside VII, sitoindoside VIII, and withanoside IV.
  • Minor Chemical Constituents: Flavonoids, Amino acids, Volatile oils

Uses:

  • Ashwagandha is used as an adaptogen, which means it helps the body cope with stress and anxiety.
  • Enhancing the brain function and memory.
  • Ashwagandha is used for improving the sexual health and fertility of both men and women.
  • Ashwagandha is used for strengthening the immune system and reducing inflammation.

Tulsi

Synonym:

English: holy basil, sacred basil, Indian basil
Hindi & Marathi: Tulsi or Tulasi.

Biological Source:

Derived from the fresh or dried leaves and flowering tops of Ocimum sanctum (syn. *Ocimum tenuiflorum*).

Tulsi native to India.

Family:

Lamiaceae (Labiatae)

Chemical Constituents:

  • Major Chemical Constituents: Include essential oil, tannins, flavonoids, phenolic acids, and triterpenoids.
  • The essential oil consists mostly of eugenol (~70%), β-elemene (~11%), β-caryophyllene (~8%), and germacrene.
  • Minor Chemical Constituents: The major flavonoids are orientin and vicenin, which have immunomodulatory and neuroprotective effects

Uses:

Tulsi has been shown to have adaptogenic, antimicrobial, anti-inflammatory, cardioprotective, antidiabetic, hepatoprotective, anticancer, and antistress effects

Guggul

Synonym:

English: gum guggul, guggula, gugul, Indian bdellium
Marathi: guggala

Biological Source:

Oleo-gum resin obtained by incision of the bark of Commiphora wightii (syn. *Commiphora mukul*).

Family:

Burseraceae

Chemical Constituents:

  • Major Chemical Constituents: Contains gum (32%), essential oil (1.45%), sterols (guggulsterones I to VI, β-sitosterol, cholesterol, Z- and E-guggulsterone).
  • The major constituents responsible for activity are guggulsterone E and Z, which are noted for lipid-lowering and potential weight reduction property.
  • Minor Chemical Constituents: sugars (sucrose, fructose), amino acids

Uses:

  • Guggul is praised for its anti-inflammatory properties, treat certain anti-inflammatory conditions, such as acne, eczema, psoriasis, and arthritis.
  • It has also been used to promote weight loss, treat hypothyroidism
  • Lipid-lowering (cholesterol and triglycerides) is a primary investigated use.
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